Turmeric
Common Names: turmeric, turmeric root, Indian saffron
Latin Names: Curcuma longa, synonym Curcuma domestica; Curcuma aromatica
Background
Turmeric, a plant in the ginger family, is native to Southeast Asia and is grown commercially in that region, primarily in India. Its rhizome (underground stem) is used as a culinary spice and traditional medicine.
Historically, turmeric was used in Ayurveda and other traditional Indian medical systems, as well as Eastern Asian medical systems such as traditional Chinese medicine. In India, it was traditionally used for disorders of the skin, upper respiratory tract, joints, and digestive system.
Today, turmeric is promoted as a dietary supplement for a variety of conditions, including arthritis, digestive disorders, respiratory infections, allergies, liver disease, depression, and many others.
Turmeric is a common spice and a major ingredient in curry powder. Curcumin is a major component of turmeric, and the activities of turmeric are commonly attributed to curcuminoids (curcumin and closely related substances). Curcumin gives turmeric its yellow color.
Turmeric dietary supplements are made from the dried rhizome and typically contain a mixture of curcuminoids. Turmeric is also made into a paste for skin conditions.
Curcumin -Antioxidants help fight cell damaging free radicals in the body and free radicals contribute to oxidative stress, which in turn can lead to the premature aging of cells.AlgEnergy Nutra Curcumin Capsules has a number of benefits for heart, brain, skin, and gut health besides helping maintain healthy immunity.
Curcumin has 500 Mg Of Turmeric Curcumin With 95% Standardized Curcuminoids Per Serving (Highest Potency) And 10Mg Of Bioperine (Black Pepper, Curcumin With Black Pepper) For Enhanced Absorption
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Curcumin with Bioperine supplement maintains that body’s natural immunity that weaken with age. Curcumin with Bioperine Capsule is a powerful anti-inflammatory ingredient used in relieving joint pain, inflammation, swelling, soreness & redness.
Turmeric and Curcumin helps in making your skin glow naturally by diminishing blemishes, fine lines & wrinkles.
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Anti-Oxidant Activity
Antioxidant activity of herbs shows function in health management via its role in neutralization of free radical species. Finding based on in vitro showed that curcumin is an effective scavenger of ROS and reactive nitrogen species and in other finding, the antioxidant activity was established by inhibition of controlled initiation of styrene oxidation. The effective anticancer property of curcumin is attributed to its antioxidant effect that control DNA damage and free radical–mediated lipid peroxidation.
It also exerts powerful inhibitory effect against hydrogen peroxide-induced damage in human keratinocytes and fibroblasts.In addition, curcumin, chief constituents of turmeric shows role in the improvement of the activities of detoxifying enzymes such as glutathione-S-transferase (GST). Earlier study reported that curcumin efficiently inhibits intracellular amyloid toxicity at low dosages based on rats through its free radical scavenging activity.
Experiment based on rat model confirmed that oral administration of curcumin showed noteworthy reversal in lipid peroxidation, brain lipids as well as produced enhancement of glutathione.
Anti–inflammatory activity
Nonsteroidal anti-inflammatory drugs are most commonly used drugs worldwide in the treatment of inflammation and are approved for orthopedic conditions and wound. However, such drugs show an adverse side effect and causes gastric ulcer. Curcumin have shown a vital effect in the prevention of inflammatory process via modulation or inhibition of various molecular pathways
The Arthritis Foundation cites several studies in which turmeric has reduced inflammation.This anti-inflammatory ability might reduce the aggravation that people with arthritis feel in their joints. The foundation suggests taking capsules of 400 to 600 milligrams (mg) of turmeric up to three times per day for inflammation relief.
Photo-protection activity
Medicinal plants are rich source of antioxidant and antioxidant activity of plants shows importance in the neutralization of adverse effect of ultraviolet (UV) light. Curcumin plays an important role in control of various types of pathogenesis and also shows a role in skin protector due to antioxidant activity. The previous study based on flow cytometric analysis revealed that increase in intracellular oxidative stress caused by UV irradiation could be abolished by curcumin.
Effect on Hypertension
Hypertension and associated complication is a one of the culprits in the pathogenesis of diseases. In this concerned, curcumin has proven an important role in the prevention of hypertension . Earlier finding concluded that increase of blood pressure due to N-nitro-L-arginine-methylester can be partially prevented by piperine or curcumin, the result of combination of curcumin and piperine being less significant and other finding showed that hypertension reducing the effect of curcumin
Anti-Diabetic Activity
Study was performed to check the effects of curcumin and it was found that administration of curcumin enhanced the activities of all antioxidant enzymes. F
urthermore, curcumin treated rats has shown noteworthy increase in gene expression such as insulin-like growth factor-1, B-cell lymphoma 2, superoxide dismutase and GST as compared groups such as nondiabetic and diabetic untreated rats..Another study based on rat showed that insulin secretion, heme oxygenase (HO)-1 gene expression and HO activity were significantly increased after isolated islets of Langerhans treated in curcumin. Recent study summarized the role of curcumin in the prevention or delaying of diabetic retinopathy via modulation of various biological activities and oral administration of curcumin with dose 0.05% w/w in diets for 9 weeks showed role in the inhibition of diabetes-induced increase in acetylated histones in the retinas
Anti-Obesity effect
Obesity is a major health problem worldwide, and it is also causes various types of pathogenesis. A study results demonstrated that curcumin improves insulin signaling, glucose disposal, as well as blocks obesity during high-fat diet consumption.Curcumin therapy ameliorates the inflammatory consequences of obesity in murine obesity models as compared to control obese animals. In addition, curcumin treated obese animals also showed decreased NF-κB activity in liver tissue. Oral curcumin supplementation was shown to prevent the development of obesity-associated inflammation, insulin resistance, and diabetes. Curcumin at cellular and whole organism levels shows potential health benefits for prevention of obesity and associated metabolic disorders through suppressing angiogenesis in adipose tissue, up-regulating adipocyte energy metabolism.
Immunomodulatory Effect
Immunomodulatory process plays an important role in the modulations of immune system either by enhance the immune response or suppressing the immune response. Curcumin, active compound of turmeric shows pivotal role in the modulation of immune system.
Effect on Respiratory Disorder
Respiratory disorder such as asthma, bronchitis, and cold coughs rapidly increasing worldwide due to the continuous increasing of environmental pollutants. Currently used drugs in this prospective are not a permanent solution and also causes other adverse complications. Curcumin shows a valuable role in the control of respiratory related complications
Anti-Tumor Activity
Numerous natural products or products based on plant seed, flower, leaves, and stem have confirmed their role in tumor prevention. Curcumin, chief constituent of turmeric has been shown to inhibit the activity of the drug-metabolizing enzymes .
A study finding reported that curcumin is able to induce apoptosis and inhibit the proliferation of melanoma cells.
Conclusion
Curcumin has received worldwide attention for its multiple health benefits, which appear to act primarily through its anti-oxidant and anti-inflammatory mechanisms. These benefits are best achieved when curcumin is combined with agents such as piperine, which increase its bioavailability significantly. Research suggests that curcumin can help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and subsequent performance in active people. In addition, a relatively low dose can provide health benefits for people that do not have diagnosed health conditions.
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