Turmeric
Common Names: turmeric, turmeric root, Indian saffron
Latin Names: Curcuma longa, synonym Curcuma domestica; Curcuma aromatica
Background
Turmeric, a plant in the ginger family, is native to Southeast Asia and is grown commercially in that region, primarily in India. Its rhizome (underground stem) is used as a culinary spice and traditional medicine.
Historically, turmeric was used in Ayurveda and other traditional Indian medical systems, as well as Eastern Asian medical systems such as traditional Chinese medicine. In India, it was traditionally used for disorders of the skin, upper respiratory tract, joints, and digestive system.
Today, turmeric is promoted as a dietary supplement for a variety of conditions, including arthritis, digestive disorders, respiratory infections, allergies, liver disease, depression, and many others.
Turmeric is a common spice and a major ingredient in curry powder. Curcumin is a major component of turmeric, and the activities of turmeric are commonly attributed to curcuminoids (curcumin and closely related substances). Curcumin gives turmeric its yellow color.
Turmeric dietary supplements are made from the dried rhizome and typically contain a mixture of curcuminoids. Turmeric is also made into a paste for skin conditions.
Curcumin -Antioxidants help fight cell damaging free radicals in the body and free radicals contribute to oxidative stress, which in turn can lead to the premature aging of cells.AlgEnergy Nutra Curcumin Capsules has a number of benefits for heart, brain, skin, and gut health besides helping maintain healthy immunity.
Curcumin has 500 Mg Of Turmeric Curcumin With 95% Standardized Curcuminoids Per Serving (Highest Potency) And 10Mg Of Bioperine (Black Pepper, Curcumin With Black Pepper) For Enhanced Absorption
Our Turmeric extract With Bioperine Is Third Party Tested To Assure The Highest Quality And Purity Of Each Batch Highest Potency Available Turmeric Enhanced With Bioperine
Curcumin with Bioperine supplement maintains that body’s natural immunity that weaken with age. Curcumin with Bioperine Capsule is a powerful anti-inflammatory ingredient used in relieving joint pain, inflammation, swelling, soreness & redness.
Turmeric and Curcumin helps in making your skin glow naturally by diminishing blemishes, fine lines & wrinkles.
This curcumin is also free of soy, gluten, milk, egg, wheat, GMOs, peanuts, sweeteners, shellfish and sugar
Amazon Buy link: https://amzn.to/3df99UR
Anti-Oxidant Activity
Antioxidant activity of herbs shows function in health management via its role in neutralization of free radical species. Finding based on in vitro showed that curcumin is an effective scavenger of ROS and reactive nitrogen species and in other finding, the antioxidant activity was established by inhibition of controlled initiation of styrene oxidation. The effective anticancer property of curcumin is attributed to its antioxidant effect that control DNA damage and free radical–mediated lipid peroxidation.
It also exerts powerful inhibitory effect against hydrogen peroxide-induced damage in human keratinocytes and fibroblasts.In addition, curcumin, chief constituents of turmeric shows role in the improvement of the activities of detoxifying enzymes such as glutathione-S-transferase (GST). Earlier study reported that curcumin efficiently inhibits intracellular amyloid toxicity at low dosages based on rats through its free radical scavenging activity.
Experiment based on rat model confirmed that oral administration of curcumin showed noteworthy reversal in lipid peroxidation, brain lipids as well as produced enhancement of glutathione.
Anti–inflammatory activity
Nonsteroidal anti-inflammatory drugs are most commonly used drugs worldwide in the treatment of inflammation and are approved for orthopedic conditions and wound. However, such drugs show an adverse side effect and causes gastric ulcer. Curcumin have shown a vital effect in the prevention of inflammatory process via modulation or inhibition of various molecular pathways
The Arthritis Foundation cites several studies in which turmeric has reduced inflammation.This anti-inflammatory ability might reduce the aggravation that people with arthritis feel in their joints. The foundation suggests taking capsules of 400 to 600 milligrams (mg) of turmeric up to three times per day for inflammation relief.
Photo-protection activity
Medicinal plants are rich source of antioxidant and antioxidant activity of plants shows importance in the neutralization of adverse effect of ultraviolet (UV) light. Curcumin plays an important role in control of various types of pathogenesis and also shows a role in skin protector due to antioxidant activity. The previous study based on flow cytometric analysis revealed that increase in intracellular oxidative stress caused by UV irradiation could be abolished by curcumin.
Effect on Hypertension
Hypertension and associated complication is a one of the culprits in the pathogenesis of diseases. In this concerned, curcumin has proven an important role in the prevention of hypertension . Earlier finding concluded that increase of blood pressure due to N-nitro-L-arginine-methylester can be partially prevented by piperine or curcumin, the result of combination of curcumin and piperine being less significant and other finding showed that hypertension reducing the effect of curcumin
Anti-Diabetic Activity
Study was performed to check the effects of curcumin and it was found that administration of curcumin enhanced the activities of all antioxidant enzymes. F
urthermore, curcumin treated rats has shown noteworthy increase in gene expression such as insulin-like growth factor-1, B-cell lymphoma 2, superoxide dismutase and GST as compared groups such as nondiabetic and diabetic untreated rats..Another study based on rat showed that insulin secretion, heme oxygenase (HO)-1 gene expression and HO activity were significantly increased after isolated islets of Langerhans treated in curcumin. Recent study summarized the role of curcumin in the prevention or delaying of diabetic retinopathy via modulation of various biological activities and oral administration of curcumin with dose 0.05% w/w in diets for 9 weeks showed role in the inhibition of diabetes-induced increase in acetylated histones in the retinas
Anti-Obesity effect
Obesity is a major health problem worldwide, and it is also causes various types of pathogenesis. A study results demonstrated that curcumin improves insulin signaling, glucose disposal, as well as blocks obesity during high-fat diet consumption.Curcumin therapy ameliorates the inflammatory consequences of obesity in murine obesity models as compared to control obese animals. In addition, curcumin treated obese animals also showed decreased NF-κB activity in liver tissue. Oral curcumin supplementation was shown to prevent the development of obesity-associated inflammation, insulin resistance, and diabetes. Curcumin at cellular and whole organism levels shows potential health benefits for prevention of obesity and associated metabolic disorders through suppressing angiogenesis in adipose tissue, up-regulating adipocyte energy metabolism.
Immunomodulatory Effect
Immunomodulatory process plays an important role in the modulations of immune system either by enhance the immune response or suppressing the immune response. Curcumin, active compound of turmeric shows pivotal role in the modulation of immune system.
Effect on Respiratory Disorder
Respiratory disorder such as asthma, bronchitis, and cold coughs rapidly increasing worldwide due to the continuous increasing of environmental pollutants. Currently used drugs in this prospective are not a permanent solution and also causes other adverse complications. Curcumin shows a valuable role in the control of respiratory related complications
Anti-Tumor Activity
Numerous natural products or products based on plant seed, flower, leaves, and stem have confirmed their role in tumor prevention. Curcumin, chief constituent of turmeric has been shown to inhibit the activity of the drug-metabolizing enzymes .
A study finding reported that curcumin is able to induce apoptosis and inhibit the proliferation of melanoma cells.
Conclusion
Curcumin has received worldwide attention for its multiple health benefits, which appear to act primarily through its anti-oxidant and anti-inflammatory mechanisms. These benefits are best achieved when curcumin is combined with agents such as piperine, which increase its bioavailability significantly. Research suggests that curcumin can help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and subsequent performance in active people. In addition, a relatively low dose can provide health benefits for people that do not have diagnosed health conditions.
LINKS & REFERENCES:
Curcumin, a component of golden spice: from bedside to bench and back.Prasad S, Gupta SC, Tyagi AK, Aggarwal BB.Biotechnol Adv. 2014 Nov 1;32(6):1053-64. doi: 10.1016/j.biotechadv.2014.04.004. Epub 2014 Apr 30.PMID: 24793420 Review.
Multitargeting by turmeric, the golden spice: From kitchen to clinic.Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB.Mol Nutr Food Res. 2013 Sep;57(9):1510-28. doi: 10.1002/mnfr.201100741. Epub 2012 Aug 13.PMID: 22887802 Review.
Curcumin: the Indian solid gold.Aggarwal BB, Sundaram C, Malani N, Ichikawa H.Adv Exp Med Biol. 2007;595:1-75. doi: 10.1007/978-0-387-46401-5_1.PMID: 17569205 Review.
Curcumin, an active component of turmeric (Curcuma longa), and its effects on health.Kocaadam B, Şanlier N.Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895. doi: 10.1080/10408398.2015.1077195.PMID: 26528921 Review.
Prevention of Cardiovascular Diseases with Anti-Inflammatory and Anti- Oxidant Nutraceuticals and Herbal Products: An Overview of Pre-Clinical and Clinical Studies.Jain S, Buttar HS, Chintameneni M, Kaur G.Recent Pat Inflamm Allergy Drug Discov. 2018;12(2):145-157. doi: 10.2174/1872213X12666180815144803.PMID: 30109827 Review.
Ten Health Benefits of Turmeric and Curcumin | Healthline https://www.healthline.com/nutrition/
Top-10-evidence-based-health-benefits-of-turmeric Turmeric | NCCIH https://www.nccih.nih.gov/health/turmeric
The positive and negative health effects of turmeric | Medical New Today https://www.medicalnewstoday.com/articles/318405
What Are the Benefits of Turmeric? - The New York Times https://www.nytimes.com/2019/10/16/style/self-care/turmeric-benefits.html
Curcumin: A Review of Its’ Effects on Human Health | Foods. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/
Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research | Altern Med Rev. https://pubmed.ncbi.nlm.nih.gov/19594223
Therapeutic effects of turmeric in several diseases: An overview | Chem Biol Interact. https://pubmed.ncbi.nlm.nih.gov/31255636
Role of Curcumin in Disease Prevention and Treatment | Adv Biomed Res. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852989
Antioxidant and anti-inflammatory properties of curcumin | Adv Exp Med Biol. https://pubmed.ncbi.nlm.nih.gov/17569207
Turmeric | PubMed
Dei Cas M, Ghidoni R. Dietary curcumin: correlation between bioavailability and health potential. Nutrients. 2019;11(9):2147.
Friesen JB, Liu Y, Chen S-N, et al. Selective depletion and enrichment of constituents in “curcumin” and other Curcuma longa preparations. Journal of Natural Products. 2019;82(3):621-630.
Funk JL. Turmeric. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements, 2nd ed. New York, NY: Informa Healthcare; 2010:754-765.
Gescher A. Editorial: curcumin: recent insights, novel developments, new challenges. Molecular Nutrition & Food Research. 2013;57(9):1509.
Heger M. Don’t discount all curcumin trial data. Nature. 2017;543(7643):40.
Lopresti AL. The problem of curcumin and its bioavailability: could its gastrointestinal influence contribute to its overall health-enhancing effects? Advances in Nutrition. 2018;9(1):41-50.
Nelson KM, Dahlin JL, Bisson J, et al. Curcumin may (not) defy science. ACS Medicinal Chemistry Letters. 2017;8(5):467-470.
Nelson KM, Dahlin JL, Bisson J, et al. The essential medicinal chemistry of curcumin. Journal of Medicinal Chemistry. 2017;60(5):1620-1637.
Shen L, Ji H-F. The pharmacology of curcumin: is it the degradation products? Trends in Molecular Medicine. 2012;18(3):138-144.
Sorkin BC, Kuszak AJ, Bloss G, et al. Improving natural product research translation. FASEB Journal. 2020;34(1):41-65.
Turmeric. Natural Medicines website. Accessed at naturalmedicines.therapeuticresearch.com on December 27, 2019. [Database subscription].
Priyadarsini K.I. The chemistry of curcumin: From extraction to therapeutic agent. Molecules. 2014;19:20091–20112. doi: 10.3390/molecules191220091. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Gupta S.C., Patchva S., Aggarwal B.B. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. AAPS J. 2013;15:195–218. doi: 10.1208/s12248-012-9432-8. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Aggarwal B.B., Kumar A., Bharti A.C. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 2003;23:363–398. [PubMed] [Google Scholar]
Lestari M.L., Indrayanto G. Curcumin. Profiles Drug Subst. Excip. Relat. Methodol. 2014;39:113–204. [PubMed] [Google Scholar]
Mahady G.B., Pendland S.L., Yun G., Lu Z.Z. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res. 2002;22:4179–4181. [PubMed] [Google Scholar]
Reddy R.C., Vatsala P.G., Keshamouni V.G., Padmanaban G., Rangarajan P.N. Curcumin for malaria therapy. Biochem. Biophys. Res. Commun. 2005;326:472–474. doi: 10.1016/j.bbrc.2004.11.051. [PubMed] [CrossRef] [Google Scholar]
Vera-Ramirez L., Perez-Lopez P., Varela-Lopez A., Ramirez-Tortosa M., Battino M., Quiles J.L. Curcumin and liver disease. Biofactors. 2013;39:88–100. doi: 10.1002/biof.1057. [PubMed] [CrossRef] [Google Scholar]
Wright L.E., Frye J.B., Gorti B., Timmermann B.N., Funk J.L. Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer. Curr. Pharm. Des. 2013;19:6218–6225. doi: 10.2174/1381612811319340013. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Aggarwal B.B., Harikumar K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol. 2009;41:40–59. doi: 10.1016/j.biocel.2008.06.010. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Panahi Y., Hosseini M.S., Khalili N., Naimi E., Simental-Mendia L.E., Majeed M., Sahebkar A. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed. Pharmacother. 2016;82:578–582. doi: 10.1016/j.biopha.2016.05.037. [PubMed] [CrossRef] [Google Scholar]
Kuptniratsaikul V., Dajpratham P., Taechaarpornkul W., Buntragulpoontawee M., Lukkanapichonchut P., Chootip C., Saengsuwan J., Tantayakom K., Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clin. Interv. Aging. 2014;9:451–458. doi: 10.2147/CIA.S58535. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Mazzolani F., Togni S. Oral administration of a curcumin-phospholipid delivery system for the treatment of central serous chorioretinopathy: A 12-month follow-up study. Clin. Ophthalmol. 2013;7:939–945. doi: 10.2147/OPTH.S45820. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Allegri P., Mastromarino A., Neri P. Management of chronic anterior uveitis relapses: Efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin. Ophthalmol. 2010;4:1201–1206. doi: 10.2147/OPTH.S13271. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Trujillo J., Chirino Y.I., Molina-Jijón E., Andérica-Romero A.C., Tapia E., Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013;1:448–456. doi: 10.1016/j.redox.2013.09.003. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Anand P., Kunnumakkara A.B., Newman R.A., Aggarwal B.B. Bioavailability of curcumin: Problems and promises. Mol. Pharm. 2007;4:807–818. doi: 10.1021/mp700113r. [PubMed] [CrossRef] [Google Scholar]
Han H.K. The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin. Drug Metab. Toxicol. 2011;7:721–729. doi: 10.1517/17425255.2011.570332. [PubMed] [CrossRef] [Google Scholar]
Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., Srinivas P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64:353–356. doi: 10.1055/s-2006-957450. [PubMed] [CrossRef] [Google Scholar]
Basnet P., Skalko-Basnet N. Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 2011;16:4567–4598. doi: 10.3390/molecules16064567. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Lao C.D., Ruffin M.T., Normolle D., Heath D.D., Murray S.I., Bailey J.M., Boggs M.E., Crowell J., Rock C.L., Brenner D.E. Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med. 2006;6:10. doi: 10.1186/1472-6882-6-10. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Kunnumakkara A.B., Bordoloi D., Harsha C., Banik K., Gupta S.C., Aggarwal B.B. Curcumin mediates anticancer effects by modulating multiple cell signaling pathways. Clin. Sci. 2017;131:1781–1799. doi: 10.1042/CS20160935. [PubMed] [CrossRef] [Google Scholar]
Lin Y.G., Kunnumakkara A.B., Nair A., Merritt W.M., Han L.Y., Armaiz-Pena G.N., Kamat A.A., Spannuth W.A., Gershenson D.M., Lutgendorf S.K., et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway. Clin. Cancer Res. 2007;13:3423–3430. doi: 10.1158/1078-0432.CCR-06-3072. [PubMed] [CrossRef] [Google Scholar]
Marchiani A., Rozzo C., Fadda A., Delogu G., Ruzza P. Curcumin and curcumin-like molecules: From spice to drugs. Curr. Med. Chem. 2014;21:204–222. doi: 10.2174/092986732102131206115810. [PubMed] [CrossRef] [Google Scholar]
Sahebkar A., Serbanc M.C., Ursoniuc S., Banach M. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. J. Funct. Foods. 2015;18:898–909. doi: 10.1016/j.jff.2015.01.005. [CrossRef] [Google Scholar]
Banach M., Serban C., Aronow W.S., Rysz J., Dragan S., Lerma E.V., Apetrii M., Covic A. Lipid, blood pressure and kidney update 2013. Int. Urol. Nephrol. 2014;46:947–961. doi: 10.1007/s11255-014-0657-6. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Menon V.P., Sudheer A.R. Antioxidant and anti-inflammatory properties of curcumin. Adv. Exp. Med. Biol. 2007;595:105–125. [PubMed] [Google Scholar]
Panahi Y., Alishiri G.H., Parvin S., Sahebkar A. Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial. J. Diet. Suppl. 2016;13:209–220. doi: 10.3109/19390211.2015.1008611. [PubMed] [CrossRef] [Google Scholar]
Priyadarsini K.I., Maity D.K., Naik G.H., Kumar M.S., Unnikrishnan M.K., Satav J.G., Mohan H. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic. Biol. Med. 2003;35:475–484. doi: 10.1016/S0891-5849(03)00325-3. [PubMed] [CrossRef] [Google Scholar]
Biswas S.K. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid. Med. Cell. Longev. 2016;2016:5698931. doi: 10.1155/2016/5698931. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Jurenka J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev. J. Clin. Ther. 2009;14:141–153. [PubMed] [Google Scholar]
Recio M.C., Andujar I., Rios J.L. Anti-inflammatory agents from plants: Progress and potential. Curr. Med. Chem. 2012;19:2088–2103. doi: 10.2174/092986712800229069. [PubMed] [CrossRef] [Google Scholar]
Hunter D.J., Schofield D., Callander E. The individual and socioeconomic impact of osteoarthritis. Lancet Nat. Rev. Rheumatol. 2014;10:437–441. doi: 10.1038/nrrheum.2014.44. [PubMed] [CrossRef] [Google Scholar]
Vos T., Barber R.M., Bell B., Bertozzi-Villa A., Biryukov S., Bolliger I., Charlson F., Davis A., Degenhardt L., Dicker D., et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study. Lancet. 2013;386:743–800. doi: 10.1016/S0140-6736(15)60692-4. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Goldring M.B. Osteoarthritis and cartilage: The role of cytokines. Curr. Rheumatol. Rep. 2000;2:459–465. doi: 10.1007/s11926-000-0021-y. [PubMed] [CrossRef] [Google Scholar]
Rahimnia A.R., Panahi Y., Alishiri A., Sharafi M., Sahebkar A. Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: Findings from a randomized double-blind placebo-controlled trial. Drug Res. 2015;65:521–525. doi: 10.1055/s-0034-1384536. [PubMed] [CrossRef] [Google Scholar]
Sahebkar A. Molecular mechanisms for curcumin benefits against ischemic injury. Fertil. Steril. 2010;94:e75–e76. doi: 10.1016/j.fertnstert.2010.07.1071. [PubMed] [CrossRef] [Google Scholar]
Henrotin Y., Priem F., Mobasheri A. Curcumin: A new paradigm and therapeutic opportunity for the treatment of osteoarthritis: Curcumin for osteoarthritis management. SpringerPlus. 2013;2:56. doi: 10.1186/2193-1801-2-56. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Belcaro G., Cesarone M.R., Dugall M., Pellegrini L., Ledda A., Grossi M.G., Togni S., Appendino G. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52:55–62. [PubMed] [Google Scholar]
Belcaro G., Hosoi M., Pellegrini L., Appendino G., Ippolito E., Ricci A., Ledda A., Dugall M., Cesarone M.R., Maione C., et al. A controlled study of a lecithinized delivery system of curcumin (meriva®) to alleviate the adverse effects of cancer treatment. Phytother. Res. 2014;28:444–450. doi: 10.1002/ptr.5014. [PubMed] [CrossRef] [Google Scholar]
Chandran B., Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother. Res. 2012;26:1719–1725. doi: 10.1002/ptr.4639. [PubMed] [CrossRef] [Google Scholar]
Panahi Y., Rahimnia A.R., Sharafi M., Alishiri G., Saburi A., Sahebkar A. Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial. Phytother. Res. 2014;28:1625–1631. doi: 10.1002/ptr.5174. [PubMed] [CrossRef] [Google Scholar]
Francesco D.P., Giuliana R., Eleonora A.D.M., Giovanni A., Federico F., Stefano T. Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva®), nimesulide, and acetaminophen. J. Pain Res. 2013;6:201–205. doi: 10.2147/JPR.S42184. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Daily J.W., Yang M., Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of ioint arthritis: A Systematic review and meta-snalysis of randomized clinical trials. J. Med. Food. 2016;19:717–729. doi: 10.1089/jmf.2016.3705. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Na L.X., Li Y., Pan H.Z., Zhou X.L., Sun D.J., Meng M., Li X.X., Sun C.H. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial. Mol. Nutr. Food Res. 2013;57:1569–1577. doi: 10.1002/mnfr.201200131. [PubMed] [CrossRef] [Google Scholar]
Chuengsamarn S., Rattanamongkolgul S., Luechapudiporn R., Phisalaphong C., Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35:2121–2127. doi: 10.2337/dc12-0116. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Bradford P.G. Curcumin and obesity. Biofactors. 2013;39:78–87. doi: 10.1002/biof.1074. [PubMed] [CrossRef] [Google Scholar]
Hlavackova L., Janegova A., Ulicna O., Janega P., Cerna A., Babal P. Spice up the hypertension diet—Curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension. Nutr. Metab. 2011;8:72. doi: 10.1186/1743-7075-8-72. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Sahebkar A. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother. Res. 2013;28:633–642. doi: 10.1002/ptr.5045. [PubMed] [CrossRef] [Google Scholar]
Ak T., Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem. Biol. Interact. 2008;174:27–37. doi: 10.1016/j.cbi.2008.05.003. [PubMed] [CrossRef] [Google Scholar]
Sahebkar A., Mohammadi A., Atabati A., Rahiman S., Tavallaie S., Iranshahi M., Akhlaghi S., Ferns G.A., Ghayour-Mobarhan M. Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals. Phytother. Res. 2013;27:1883–1888. doi: 10.1002/ptr.4952. [PubMed] [CrossRef] [Google Scholar]
Mohammadi A., Sahebkar A., Iranshahi M., Amini M., Khojasteh R., Ghayour-Mobarhan M., Ferns GA. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: A randomized crossover trial. Phytother. Res. 2013;27:374–379. doi: 10.1002/ptr.4715. [PubMed] [CrossRef] [Google Scholar]
DiSilvestro R.A., Joseph E., Zhao S., Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle-aged people. Nutr. J. 2012;11:79. doi: 10.1186/1475-2891-11-79. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Sahebkar A. Curcuminoids for the management of hypertriglyceridaemia. Nat. Rev. Cardiol. 2014;11:123. doi: 10.1038/nrcardio.2013.140-c1. [PubMed] [CrossRef] [Google Scholar]
Soni K.B., Kuttan R. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J. Physiol. Pharmacol. 1992;36:273–275. [PubMed] [Google Scholar]
Panahi Y., Khalili N., Hosseini M.S., Abbasinazari M., Sahebkar A. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial. Complement. Ther. Med. 2014;22:851–857. doi: 10.1016/j.ctim.2014.07.006. [PubMed] [CrossRef] [Google Scholar]
Panahi Y., Hosseini M.S., Khalili N., Naimi E., Simental-Mendia L.E., Majeed M., Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin. Nutr. 2015;34:1101–1108. doi: 10.1016/j.clnu.2014.12.019. [PubMed] [CrossRef] [Google Scholar]
Ganjali S., Sahebkar A., Mahdipour E., Jamialahmadi K., Torabi S., Akhlaghi S., Ferns G., Parizadeh S.M.R., Ghayour-Mobarhan M. Investigation of the effects of curcumin on serum cytokines in obese individuals: A randomized controlled trial. Sci. World J. 2014;2014:898361. doi: 10.1155/2014/898361. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Strimpakos A., Sharm R. Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials. Food Chem. Toxicol. 2008;10:511–545. doi: 10.1089/ars.2007.1769. [PubMed] [CrossRef] [Google Scholar]
Epstein J., Sanderson I., Macdonald T. Curcumin as a therapeutic agent: The evidence from in vitro, animal and human studies. Br. J. Nutr. 2010;103:1545–1557. doi: 10.1017/S0007114509993667. [PubMed] [CrossRef] [Google Scholar]
Cox K.H., Pipingas A., Scholey A.B. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J. Psychopharmacol. 2015;29:642–651. doi: 10.1177/0269881114552744. [PubMed] [CrossRef] [Google Scholar]
Chilelli N.C., Ragazzi E., Valentini R., Cosma C., Ferraresso S., Lapolla A., Sartore G. Curcumin and Boswellia serrata modulate the glyco-oxidative status and lipo-oxidation in master sthletes. Nutrients. 2016;8:745. doi: 10.3390/nu8110745. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
McFarlin B.K., Venable A.S., Henning A.L., Sampson J.N., Pennel K., Vingren J.L., Hill D.W. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 2016;5:72–78. doi: 10.1016/j.bbacli.2016.02.003. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Drobnic F., Riera J., Appendino G., Togni S., Franceschi F., Valle X., Pons A., Tur J. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): A randomised, placebo-controlled trial. J. ISSN. 2014;11:31. doi: 10.1186/1550-2783-11-31. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Delecroix B., Abaïdia A.E., Leduc C., Dawson B., Dupont G. Curcumin and piperine supplementation and recovery following exercise induced muscle damage: A randomized controlled trial. J. Sports Sci. Med. 2017;16:147–153. [PMC free article] [PubMed] [Google Scholar]
Esmaily H., Sahebkar A., Iranshahi M., Ganjali S., Mohammadi A., Ferns G., Ghayour-Mobarhan M. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin. J. Integr. Med. 2015;21:332–338. doi: 10.1007/s11655-015-2160-z. [PubMed] [CrossRef] [Google Scholar]
Kocaadam B., Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 2017;57:2889–2895. doi: 10.1080/10408398.2015.1077195. [PubMed] [CrossRef] [Google Scholar]
Sharma R.A., Euden S.A., Platton S.L., Cooke D.N., Shafayat A., Hewitt H.R., Marczylo T.H., Morgan B., Hemingway D., Plummer S.M. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin. Cancer Res. 2004;10:6847–6854. doi: 10.1158/1078-0432.CCR-04-0744. [PubMed] [CrossRef] [Google Scholar]
Comentarios